Hi.

1900 Holmes County, Beat 1, Mississippi, ED 35

Jerry Cothran,Head, 1835(65), Wd, Farmer, MS MS MS
Jane Cothran, daughter, 1884(16)
Alfred Cothran, son, 1881(19)
Jonas Cothran, son, 1888(12)

1880 Holmes County, Beat 1, Mississippi, ED 1

Jerry Cothran, Head,35
Jinny Cothran, wife, 30
Westly Cothran, son, 17
James Cothran, son, 12
Jerry Cothran, son, 1

1870 Holmes County, Lexington, Mississippi

Joe Cothran,40, farmer
Nancy Cothran, 30
Henry Cothran, 18

Next family down

Gerry Cothran, 38, farmer
Jane Cothran, 25
William Cothran, 10
Jessie Cothran, 7
Wesley Cothran, 2

Ages aside, this looks like them to me. Also likely that Joe is the brother, that's why I included him.

Possible slave holders in 1860 Holmes County:

COTHRAN JAMES 55 M W SC MS HOLMES DARK CORNER 1860

COTHRAN JAMES H 36 M W SC MS HOLMES DARK CORNER 1860