Could you be a bit more specific - when was she living - who are her children, spouse, parents? How are you connected? There are listings in N'Orleans records for that surname - and other spelling variations but without knowing more about your search it will be hard to know what to post.

For example - here is a marriage listing:

Name: Mary E. Lyons
Spouse: D. W. Taliaferro
Gender: F
Marriage Date: 09 Jun 1876
Volume: 5
Page: 697

Denise