Thanks for your time Mr. Collier!

I need to make some clarifications:
The slave division was part of the estate records. Dyer County had a court fire in the early 1850s where almost all records were destroyed, the Will book from this period did not survive. The division is from the deed books, I did not explain that previously.

I have not found Francis either in any censuses or other documents (at least none I can say for sure is the 'right' Francis, I also looked for children with names of Isham or Eliza).

Elijah did most likely pass away before 1880 when his wife is living alone with six children.

Some more thoughts:

Here is what I DO like:
The values of the lots in the slave division are more spread out than most if not all other slave divisions I've seen. To me it looks like other beliefs than strictly monetary values decided the lots. I'm hoping for that lots were more decided by trying to keep the families together where possible.

And I also off course like that since they are named as husband and wife (in two different documents) they are as you say likely to have had children and that they seem to be in the right age for having children.

Here is what I DO NOT like, please tell me what you think:
The fact that Charles Henderson Hood sold only Isham and Eliza but not the entire family to Mathew Tomlin. Dyer County and Madison County are not neighbor counties. Would he sell the parents but not very small children? Or could he have kept Elijah and Francis since their real parents (who were not Isham and Eliza) were still in Dyer County? To me it seems more practical and also more human (and would bring more money too) if the entire family was sold.

I also do not like that I can't find Francis anywhere. Since the bill of sale from Charles Henderson Hood to Mathew Tomlin was recorded in Madison County and not his native Dyer County, maybe to be sure I need to check more counties to see if he sold Francis. Based on 1850 and 1860 slave schedules I firmly believe that she was no longer with Charles Henderson Hood.

If I put the pros and cons against each other I would still go with what I DO like weighs more than what I DO NOT like.

I guess my question is: If Elijah was your ancestor, would you add Isham and Eliza to your family tree?